Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9750009 | 0.86 | CHRNA7 (0.46) | MAPTMAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL11019682 | 0.80 | MAPT (0.40) | MAPTTDP1MAPK1L3MBTL1FFAR4 | |
| SCHEMBL9750432 | 0.80 | HRH3 (0.48) | HRH3MEN1KMT2ACYP3A4NPC1 | |
| SCHEMBL11019035 | 0.80 | HRH3 (0.48) | SLC6A2SLC6A3HRH3MEN1KMT2A | |
| SCHEMBL11149823 | 0.76 | MAPT (0.47) | MAPTTDP1MAPK1L3MBTL1BRD4 | |
| SCHEMBL9750259 | 0.75 | MAPT (0.46) | MAPTTDP1MAPK1L3MBTL1BRD4 | |
| SCHEMBL9750254 | 0.75 | HRH3 (0.40) | TDP1L3MBTL1SMN1; SMN2HRH3MRGPRX4 | |
| SCHEMBL9750186 | 0.73 | PTPN1 (0.40) | MAPTTDP1MAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL6092178 | 0.73 | MPI (0.50) | MAPTTDP1HTTMPIMEN1 | |
| SCHEMBL25081934 | 0.72 | MAPT (0.64) | MAPTTDP1MAPK1L3MBTL1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120858-A | Condensation of 2-methyleneindoline and formic acid in acetic anhydride | MILES INC. (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0058863-B1 | PROCESS FOR THE PREPARATION OF TRIMETHINE DYESTUFFS | BAYER AG (DE) | 1985-01-23 | — | — | EP | disclosed |
| US-4419511-A | Process for the preparation of trimethine dyestuffs | BAYER AKTIENGESELLSCHAFT (US) | 1983-12-06 | — | — | US | disclosed |
| EP-0058863-A1 | Process for the preparation of trimethine dyestuffs | BAYER AG (DE) | 1982-09-01 | — | — | EP | disclosed |