Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 5/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.30 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9751010 | 0.80 | HMGCR (0.49) | HMGCRTGFBR1ADORA2AADORA1TGFBR2 | |
| SCHEMBL9750803 | 0.79 | HMGCR (0.49) | HMGCRTGFBR1TGFBR2GAAMAPK13 | |
| SCHEMBL9732188 | 0.73 | PKM (0.37) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9518155 | 0.73 | HMGCR (0.53) | HMGCRTGFBR1ADORA2AADORA1TGFBR2 | |
| SCHEMBL9518177 | 0.72 | HMGCR (0.47) | HMGCR | |
| SCHEMBL9750967 | 0.71 | HMGCR (0.47) | HMGCRABCB1KDM4EGAASMN1; SMN2 | |
| SCHEMBL9764350 | 0.70 | KDM4E (0.43) | HMGCRKDM4EALDH1A1 | |
| SCHEMBL9751046 | 0.69 | HMGCR (0.55) | HMGCRADORA2AADORA1ALDH1A1MAPK13 | |
| SCHEMBL9750986 | 0.68 | ABCB1 (0.52) | HMGCRABCB1KDM4EALDH1A1GAA | |
| SCHEMBL9024316 | 0.68 | PTGS2 (0.33) | HMGCRKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5055484-A | Anticholesterol and antilipemic agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-08 | — | — | US | disclosed |