Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 7/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9750945 | 0.86 | HMGCR (0.56) | HMGCRADORA2AADORA1PTGS2PTGS1 | |
| SCHEMBL9518437 | 0.86 | HMGCR (0.56) | HMGCRADORA2AADORA1PTGS2PTGS1 | |
| SCHEMBL9750845 | 0.84 | HMGCR (0.56) | HMGCRADORA2AADORA1ALDH1A1PTGS2 | |
| SCHEMBL9518155 | 0.81 | HMGCR (0.53) | HMGCRADORA2AADORA1ALDH1A1MAPK13 | |
| SCHEMBL9750837 | 0.78 | HMGCR (0.58) | HMGCRALDH1A1PTGS2 | |
| SCHEMBL9751010 | 0.77 | HMGCR (0.49) | HMGCRADORA2AADORA1ALDH1A1 | |
| SCHEMBL9518373 | 0.76 | HMGCR (0.58) | HMGCRPTGS2PTGS1MAPK13MAPK12 | |
| SCHEMBL9024748 | 0.75 | ELAVL1 (0.45) | HMGCRPTGS2PTGS1 | |
| SCHEMBL9518177 | 0.75 | HMGCR (0.47) | HMGCR | |
| SCHEMBL9764350 | 0.75 | KDM4E (0.43) | HMGCRALDH1A1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5055484-A | Anticholesterol and antilipemic agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-08 | — | — | US | disclosed |