Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9752857 | 0.89 | LMNA (0.50) | MAPTKDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL4862038 | 0.84 | TAAR1 (0.40) | LMNACTSKTAAR1 | |
| SCHEMBL10418940 | 0.76 | DDB1 (0.42) | ALDH1A1 | |
| SCHEMBL17350953 | 0.76 | SLC18A2 (0.44) | — | |
| SCHEMBL4558511 | 0.72 | MEN1 (0.40) | CTSKTAAR1MEN1KMT2ACYP3A4 | |
| SCHEMBL10418525 | 0.72 | RAB9A (0.40) | MAPTKDM4EALDH1A1LMNAPOLB | |
| SCHEMBL9023097 | 0.71 | SLC18A2 (0.41) | — | |
| SCHEMBL30827366 | 0.70 | ARG1 (0.39) | MAPTLMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL30827367 | 0.70 | ARG1 (0.39) | MAPTLMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL27198590 | 0.70 | ARG1 (0.39) | MAPTLMNAMEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991007378-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS | PFIZER LIMITED (GB) | 1991-05-30 | — | — | WO | disclosed |