Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MIF | P14174 | 2/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753170 | 0.83 | MAPK14 (0.44) | MAPK14EGFRADORA2AADORA1RAF1 | |
| SCHEMBL9752865 | 0.79 | ALDH1A1 (0.49) | MAPK14EGFRADORA2AADORA1RAF1 | |
| SCHEMBL9752965 | 0.78 | MAPK14 (0.43) | MAPK14EGFRADORA2AADORA1RAF1 | |
| SCHEMBL9752947 | 0.75 | HMGCR (0.49) | HMGCR | |
| SCHEMBL9753321 | 0.74 | MAPK14 (0.44) | MAPK14EGFRADORA2AADORA1RAF1 | |
| SCHEMBL9752919 | 0.72 | SMN1; SMN2 (0.43) | EGFRADORA2AADORA1MEN1KMT2A | |
| SCHEMBL9753346 | 0.71 | GCGR (0.39) | MAPK14EGFRADORA2AADORA1RAF1 | |
| SCHEMBL9753160 | 0.70 | MAPK14 (0.41) | MAPK14EGFRADORA2AADORA1RAF1 | |
| SCHEMBL9753157 | 0.70 | MAPK14 (0.41) | MAPK14EGFRADORA2AADORA1RAF1 | |
| SCHEMBL9752979 | 0.70 | KDM4E (0.51) | EGFRADORA3MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018903-A1 | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-12 | — | — | WO | disclosed |
| CN-1056690-A | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-12-04 | — | — | CN | disclosed |