Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 4/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | MIF | P14174 | 2/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753002 | 0.90 | TGFBR1 (0.36) | TGFBR1MAPK14ADORA2AADORA1EGFR | |
| SCHEMBL9753170 | 0.87 | MAPK14 (0.44) | GCGRMAPK14ADORA2AADORA1EGFR | |
| SCHEMBL9752919 | 0.83 | SMN1; SMN2 (0.43) | GCGRADORA2AADORA1EGFRMIF | |
| SCHEMBL9753098 | 0.81 | GCGR (0.40) | GCGRTGFBR1MAPK14ADORA2AADORA1 | |
| SCHEMBL9753354 | 0.79 | PTGS2 (0.34) | TGFBR1MAPK14ADORA2AADORA1EGFR | |
| SCHEMBL9753377 | 0.78 | EGFR (0.44) | ADORA2AADORA1EGFRMIFMEN1 | |
| SCHEMBL9753419 | 0.76 | GRM2 (0.36) | GCGRMAPK14 | |
| SCHEMBL9753721 | 0.76 | PTGS2 (0.32) | MAPK14ADORA2AADORA1EGFRRAF1 | |
| SCHEMBL9753724 | 0.76 | PTGS2 (0.32) | MAPK14ADORA2AADORA1EGFRRAF1 | |
| SCHEMBL9753097 | 0.71 | HMGCR (0.45) | ADORA3ALDH1A1CYP3A4CYP2C9PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018903-A1 | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-12 | — | — | WO | disclosed |