Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | HCK | P08631 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753040 | 0.90 | PTGS2 (0.36) | PTGS2EGFRKDRMAPK14ADORA2A | |
| SCHEMBL9753724 | 0.89 | PTGS2 (0.32) | PTGS2EGFRMAPK14ADORA2AADORA1 | |
| SCHEMBL9753721 | 0.89 | PTGS2 (0.32) | PTGS2EGFRMAPK14ADORA2AADORA1 | |
| SCHEMBL9753321 | 0.87 | MAPK14 (0.44) | PTGS2EGFRMAPK14ADORA2AADORA1 | |
| SCHEMBL9753063 | 0.83 | EGFR (0.39) | PTGS2EGFRMAPK14ADORA2AADORA1 | |
| SCHEMBL9752941 | 0.81 | ALDH1A1 (0.35) | PTGS2EGFRMAPK14ADORA2AADORA1 | |
| SCHEMBL9752932 | 0.80 | PTGS2 (0.34) | PTGS2EGFRKDRMAPK14ADORA2A | |
| SCHEMBL9752930 | 0.80 | PTGS2 (0.34) | PTGS2EGFRKDRMAPK14ADORA2A | |
| SCHEMBL9753346 | 0.79 | GCGR (0.39) | EGFRMAPK14ADORA2AADORA1RAF1 | |
| SCHEMBL9753639 | 0.77 | HMGCR (0.34) | PTGS2PGRADORA3ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018903-A1 | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-12 | — | — | WO | disclosed |