Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | GCGR | P47871 | 2/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9753098 | 0.89 | GCGR (0.40) | GRM2MAPK14GCGR | |
| SCHEMBL27347534 | 0.82 | RORC (0.37) | GRM2HSD11B1TP53MAPK14CNR1 | |
| SCHEMBL9753170 | 0.82 | MAPK14 (0.44) | MAPK14GCGR | |
| SCHEMBL9753002 | 0.80 | TGFBR1 (0.36) | MAPK14 | |
| SCHEMBL9753400 | 0.80 | TP53 (0.36) | GRM2HSD11B1TP53MAPK14CNR1 | |
| SCHEMBL9753208 | 0.79 | CDC7 (0.44) | CDC7DBF4 | |
| SCHEMBL9752977 | 0.77 | TP53 (0.34) | GRM2HSD11B1TP53MAPK14JAK2 | |
| SCHEMBL9752975 | 0.77 | TP53 (0.34) | GRM2HSD11B1TP53MAPK14JAK2 | |
| SCHEMBL9753346 | 0.76 | GCGR (0.39) | MAPK14GCGR | |
| SCHEMBL9752919 | 0.75 | SMN1; SMN2 (0.43) | GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018903-A1 | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-12 | — | — | WO | disclosed |
| CN-1056690-A | PYRROLOPYRIDAZINE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-12-04 | — | — | CN | disclosed |