Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9803773 | 0.90 | PTGS1 (0.38) | CHRM1PDE4APTGS1PTGS2LMNA | |
| SCHEMBL9754176 | 0.88 | PTGS2 (0.35) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL9754056 | 0.81 | TRPM8 (0.40) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL9754025 | 0.74 | ALOX5 (0.43) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL9803529 | 0.74 | ALOX5 (0.43) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL9754028 | 0.74 | PTGS1 (0.37) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL9754195 | 0.73 | ALOX5 (0.46) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL9803532 | 0.71 | LMNA (0.35) | CHRM1PDE4APTGS1PTGS2LMNA | |
| SCHEMBL9754397 | 0.71 | FAAH (0.36) | PDE4APTGS1PTGS2LMNACYP2C9 | |
| SCHEMBL9754341 | 0.71 | FBP1 (0.35) | PTGS1PTGS2LMNACYP2C9AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | claimed |