SCHEMBL9757529

SCHEMBL9757529

CC(=O)Nc1ccc2c(c1)CNC2C

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.50
CHRNA4 P43681 1/20 0.50
CYP1A2 P05177 3/20 0.46
HTR2C P28335 2/20 0.46
HTR2B P41595 2/20 0.46
ADRA2A P08913 1/20 0.46
MAOA P21397 1/20 0.46
SLC6A2 P23975 1/20 0.46
SLC6A4 P31645 1/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
BAZ2B Q9UIF8 1/20 0.44
ALDH1A1 P00352 2/20 0.42
HSD17B10 Q99714 1/20 0.42
HTR2A P28223 1/20 0.42
CYP2C19 P33261 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
HTR1A P08908 1/20 0.41
HTR1D P28221 1/20 0.41
HTR1B P28222 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL9757434 0.98 CHRNB2 (0.49) CHRNB2CHRNA4CYP1A2HTR2CHTR2B
SCHEMBL8248220 0.78 PNMT (0.53) CHRNB2CHRNA4CYP1A2HTR2CHTR2B
SCHEMBL3440858 0.78 ADRA2A (0.51) CHRNB2CHRNA4CYP1A2HTR2CHTR2B
SCHEMBL2246315 0.74 CYP1A2 (0.54) CHRNB2CHRNA4CYP1A2HTR2CHTR2B
SCHEMBL9571060 0.73 CYP1A2 (0.49) CHRNB2CHRNA4CYP1A2HTR2CHTR2B
SCHEMBL531907 0.72 CYP1A2 (0.55) CHRNB2CHRNA4CYP1A2HTR2CHTR2B
Hydrochloric Acid SCHEMBL4761772 0.71 ITGB3 (0.55) CHRNB2CHRNA4CYP1A2HTR2CHTR2B
SCHEMBL7476527 0.71 PYGL (0.52) CHRNB2CHRNA4CYP1A2HTR2CHTR2B
SCHEMBL9093549 0.71 CHRNB2 (0.45) CHRNB2CHRNA4CYP1A2HTR2CHTR2B
SCHEMBL12682228 0.70 MTNR1A (0.50) CHRNB2CHRNA4CYP1A2HTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5026856-A Bactericides WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1991-06-25 US disclosed
EP-0343560-A2 Isoindoline derivative WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1989-11-29 EP disclosed