Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9759912 | 0.84 | CYP19A1 (0.49) | ADRB1LTA4H | |
| SCHEMBL9759900 | 0.80 | ADRB1 (0.52) | ADRB1KCNH2LTA4HNPC1RAB9A | |
| SCHEMBL10683912 | 0.79 | JAK2 (0.47) | ADRB1OPRD1KCNH2GRIN1GRIN2B | |
| SCHEMBL10576975 | 0.73 | IGF1R (0.47) | ADRB1OPRD1KCNH2GRIN2B | |
| SCHEMBL9514777 | 0.73 | CA1 (0.46) | ADRB1OPRD1GRIN2BSMN1; SMN2 | |
| SCHEMBL9760464 | 0.71 | TDP1 (0.58) | ADRB1KCNH2LTA4HNPC1RAB9A | |
| SCHEMBL9761013 | 0.69 | F10 (0.47) | ADRB1 | |
| SCHEMBL13669954 | 0.68 | OPRD1 (0.56) | OPRD1KCNH2SLC2A1GRIN1GRIN2B | |
| SCHEMBL18278961 | 0.68 | OPRD1 (0.54) | OPRD1KCNH2SLC2A1GRIN1GRIN2B | |
| SCHEMBL2146572 | 0.68 | CHRM4 (0.44) | OPRD1KCNH2GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057528-A | AMINO-PYRIDINE COMPOUNDS USEFUL AS ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4968704-A | PROLONG DURATION OF ACTION POTENTIAL IN CARDIAC MUSCLE AND CONDUCTING TISSUE | PFIZER INC. (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0359389-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |