Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9759732 | 0.84 | ADRB1 (0.43) | ADRB1LTA4H | |
| SCHEMBL10680167 | 0.81 | MAPT (0.47) | ALDH1A1LMNAKDM4ETDP1 | |
| SCHEMBL9759900 | 0.77 | ADRB1 (0.52) | ADRB1LTA4H | |
| SCHEMBL10580608 | 0.76 | MEN1 (0.48) | ALDH1A1LMNAKDM4ETDP1 | |
| SCHEMBL27935616 | 0.70 | SIGMAR1 (0.67) | CYP19A1SIGMAR1F2ALDH1A1LMNA | |
| SCHEMBL28401966 | 0.70 | MAPT (0.47) | ALDH1A1LMNAKDM4ETDP1 | |
| SCHEMBL9760464 | 0.69 | TDP1 (0.58) | ADRB1LTA4HALDH1A1LMNAMAPK1 | |
| SCHEMBL14799084 | 0.69 | CYP19A1 (0.89) | CYP19A1ALDH1A1 | |
| SCHEMBL9761106 | 0.69 | SIGMAR1 (0.64) | SIGMAR1LMNA | |
| SCHEMBL1517205 | 0.68 | MAPT (0.59) | ALDH1A1LMNAMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057528-A | AMINO-PYRIDINE COMPOUNDS USEFUL AS ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4968704-A | PROLONG DURATION OF ACTION POTENTIAL IN CARDIAC MUSCLE AND CONDUCTING TISSUE | PFIZER INC. (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0359389-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |