Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 6/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5632556 | 0.84 | ALDH1A1 (0.56) | NAMPTMAPTSMN1; SMN2 | |
| SCHEMBL5631723 | 0.83 | ACACB (0.45) | IDO1TDO2NAMPTACACBHRH3 | |
| SCHEMBL9759900 | 0.82 | ADRB1 (0.52) | JAK2JAK3ADRB1HRH3HDAC1 | |
| SCHEMBL10680323 | 0.81 | JAK2 (0.50) | JAK2JAK3ADRB1KCNH2CYP1A2 | |
| SCHEMBL9828313 | 0.81 | JAK2 (0.47) | JAK2JAK3ADRB1HDAC1CYP1A2 | |
| SCHEMBL5632013 | 0.80 | LMNA (0.47) | NAMPTPDE4AMAPT | |
| SCHEMBL7379121 | 0.80 | ACACB (0.43) | NAMPTACACBHRH3MAPT | |
| SCHEMBL5633968 | 0.80 | NAMPT (0.43) | NAMPTACACBHRH3 | |
| SCHEMBL5633771 | 0.80 | KMT2A (0.59) | MAPTSMN1; SMN2 | |
| SCHEMBL5633167 | 0.80 | ALDH1A1 (0.57) | NAMPTTSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057528-A | AMINO-PYRIDINE COMPOUNDS USEFUL AS ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4968704-A | PROLONG DURATION OF ACTION POTENTIAL IN CARDIAC MUSCLE AND CONDUCTING TISSUE | PFIZER INC. (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0359389-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1990-03-21 | — | — | EP | disclosed |