Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10680323 | 0.84 | JAK2 (0.50) | JAK2JAK3CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL9760149 | 0.81 | IDO1 (0.45) | JAK2JAK3HDAC1CYP2C19CYP1A2 | |
| SCHEMBL22324953 | 0.80 | ROCK2 (0.40) | JAK2JAK3HDAC1TP53ADRB1 | |
| SCHEMBL9827177 | 0.79 | TP53 (0.46) | CYP2C19CYP1A2CYP2D6TSHRTP53 | |
| SCHEMBL9759900 | 0.78 | ADRB1 (0.52) | JAK2JAK3HDAC1ADRB1ADRB2 | |
| SCHEMBL319380 | 0.78 | KEAP1 (0.52) | TP53ALDH1A1CYP2C9MAPK1LMNA | |
| SCHEMBL9828877 | 0.78 | JAK2 (0.39) | JAK2JAK3HDAC1TP53ALDH1A1 | |
| SCHEMBL10583353 | 0.77 | SIGMAR1 (0.50) | CYP2C19CYP1A2CYP2D6TSHRTP53 | |
| SCHEMBL9828015 | 0.77 | CHRNA7 (0.50) | TP53ALDH1A1CHKALMNA | |
| SCHEMBL9828873 | 0.77 | ALDH1A1 (0.40) | JAK2JAK3TP53GPR119ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291210-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1991-11-06 | — | — | EP | disclosed |
| US-4835165-A | Antiarrhythmic 4-phenylpiperidines | PFIZER INC. (US) | 1989-05-30 | — | — | US | disclosed |
| EP-0291210-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1988-11-17 | — | — | EP | disclosed |