Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.51 |
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 3/20 | 0.40 |
| ▸ | CASP7 | P55210 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9762673 | 1.00 | KCNH2 (0.51) | KCNH2HSD17B10ALDH1A1CYP1A2GLA | |
| Fumaric Acid SCHEMBL9761877 | 0.79 | TP53 (0.50) | KCNH2MAPTLMNATHRBPOLB | |
| Fumaric Acid SCHEMBL9761875 | 0.79 | TP53 (0.50) | KCNH2MAPTLMNATHRBPOLB | |
| SCHEMBL9761903 | 0.73 | PDE4A (0.50) | KCNH2ALDH1A1HPGDGAALMNA | |
| Fumaric Acid SCHEMBL9762713 | 0.73 | KCNH2 (0.62) | KCNH2MAPT | |
| Fumaric Acid SCHEMBL9762718 | 0.73 | KCNH2 (0.62) | KCNH2MAPT | |
| Fumaric Acid SCHEMBL8549995 | 0.69 | MCL1 (0.41) | ALDH1A1KDM4EMAPTUSP2L3MBTL1 | |
| Fumaric Acid SCHEMBL8549993 | 0.69 | MCL1 (0.41) | ALDH1A1KDM4EMAPTUSP2L3MBTL1 | |
| Fumaric Acid SCHEMBL9761131 | 0.67 | LMNA (0.50) | HSD17B10ALDH1A1TSHRKDM4EHPGD | |
| Fumaric Acid SCHEMBL9761122 | 0.67 | LMNA (0.50) | HSD17B10ALDH1A1TSHRKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5071855-A | Antihistamines, antiallergens | DOMPE FARMACEUTICI SPA (IT) | 1991-12-10 | — | — | US | disclosed |