Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.48 |
| ▸ | KCNH2 known ✓ | Q12809 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9761875 | 1.00 | TP53 (0.50) | TP53POLBLMNATHRBCYP2D6 | |
| SCHEMBL9761903 | 0.84 | PDE4A (0.50) | TP53LMNACYP2D6HRH1KCNH2 | |
| Fumaric Acid SCHEMBL9762673 | 0.79 | KCNH2 (0.51) | POLBLMNATHRBKCNH2MAPT | |
| Fumaric Acid SCHEMBL9762668 | 0.79 | KCNH2 (0.51) | POLBLMNATHRBKCNH2MAPT | |
| Fumaric Acid SCHEMBL9761131 | 0.75 | LMNA (0.50) | TP53POLBLMNAENPP2 | |
| Fumaric Acid SCHEMBL9761122 | 0.75 | LMNA (0.50) | TP53POLBLMNAENPP2 | |
| SCHEMBL11480609 | 0.75 | SSTR5 (0.57) | TP53POLBLMNATHRBCYP2D6 | |
| SCHEMBL9761943 | 0.73 | CYP2D6 (0.54) | TP53LMNACYP2D6HRH1KCNH2 | |
| Fumaric Acid SCHEMBL10550969 | 0.72 | TP53 (0.50) | TP53POLBLMNATHRBMAPT | |
| Fumaric Acid SCHEMBL10551798 | 0.71 | SLC6A9 (0.48) | TP53POLBLMNATHRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5071855-A | Antihistamines, antiallergens | DOMPE FARMACEUTICI SPA (IT) | 1991-12-10 | — | — | US | disclosed |
| EP-0397614-A2 | Pharmacologically active piperdinylimidazopyridines | DOMPE' FARMACEUTICI S.p.A. (IT) | 1990-11-14 | — | — | EP | disclosed |