Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 6/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9761131 | 1.00 | LMNA (0.50) | LMNAPOLBTP53KDM4EALDH1A1 | |
| SCHEMBL9761998 | 0.91 | KDM4E (0.53) | LMNATP53KDM4EALDH1A1TSHR | |
| SCHEMBL9762192 | 0.87 | KDM4E (0.49) | KDM4EALDH1A1HPGDTSHRHTT | |
| Hydrochloric Acid SCHEMBL9761957 | 0.86 | KDM4E (0.48) | KDM4EALDH1A1HPGDTSHRHTT | |
| SCHEMBL9761943 | 0.81 | CYP2D6 (0.54) | LMNATP53ALDH1A1TSHRHSD17B10 | |
| SCHEMBL12354273 | 0.76 | HTR3E (0.56) | LMNAPOLBKDM4EALDH1A1HPGD | |
| Fumaric Acid SCHEMBL9761875 | 0.75 | TP53 (0.50) | LMNAPOLBTP53ENPP2 | |
| Fumaric Acid SCHEMBL9761877 | 0.75 | TP53 (0.50) | LMNAPOLBTP53ENPP2 | |
| Fumaric Acid SCHEMBL9635941 | 0.75 | CHRM5 (0.53) | LMNATP53KDM4EALDH1A1HPGD | |
| SCHEMBL10967129 | 0.75 | HTR3A (0.71) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023256-A | Antihistamines | DOMPE FARMACEUTICI S.P.A. (IT) | 1991-06-11 | — | — | US | claimed |
| JP-3068574-A | — | — | None | — | — | JP | disclosed |
| US-5023256-A | Antihistamines | DOMPE FARMACEUTICI S.P.A. (IT) | 1991-06-11 | — | — | US | disclosed |
| JP-H0368574-A | PHARMACEUTICALLY ACTIVE AMINOIMIDAZOPYRIDINE | DOMPE FARMACEUT SPA | 1991-03-25 | — | — | JP | disclosed |