Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2096061 | 0.87 | RXRA (0.35) | — | |
| SCHEMBL2094898 | 0.77 | KCNN4 (0.32) | — | |
| SCHEMBL9168221 | 0.77 | GAA (0.45) | MEN1KMT2AALDH1A1RAB9ATDP1 | |
| SCHEMBL27561216 | 0.77 | MGLL (0.37) | MGLLALDH1A1RAB9AMAPK1 | |
| SCHEMBL2093758 | 0.77 | FLT3 (0.38) | MEN1KMT2AMGLLALDH1A1TDP1 | |
| SCHEMBL9763868 | 0.74 | KEAP1 (0.49) | KMT2AMGLLALDH1A1POLBPI4KA | |
| SCHEMBL27666308 | 0.74 | FAAH (0.43) | MGLLALDH1A1HPGDTSHRCYP1A2 | |
| SCHEMBL2089371 | 0.73 | RBP4 (0.36) | MEN1KMT2AALDH1A1TDP1MAPK1 | |
| SCHEMBL27588510 | 0.73 | NCF1 (0.36) | — | |
| SCHEMBL2092603 | 0.73 | MGLL (0.42) | MEN1KMT2AMGLLALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5066652-A | ANTIULCER AGENTS | CHIESI FARMACEUTICI S.P.A. (IT) | 1991-11-19 | — | — | US | claimed |
| EP-0301422-A2 | Thiomethyl and sulfinylmethyl derivatives having gastric acid antisecretory activity, processes for the preparation thereof and pharmaceutical compositions containing them | CHIESI FARMACEUTICI S.p.A. (IT) | 1989-02-01 | — | — | EP | claimed |