Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764429 | 0.90 | ADRB2 (0.41) | ADRB2KCNH2LMNAHTR2A | |
| SCHEMBL9764456 | 0.90 | ADRB2 (0.41) | ADRB2KCNH2LMNAHTR2A | |
| SCHEMBL10346971 | 0.90 | MC4R (0.43) | MC4RHRH4HRH3KCNH2ALDH1A1 | |
| SCHEMBL9764389 | 0.87 | ADRB2 (0.39) | ADRB2KCNH2 | |
| SCHEMBL9764329 | 0.87 | ADRB2 (0.39) | ADRB2CA12CA1CA2CA4 | |
| SCHEMBL9764371 | 0.87 | ADRB2 (0.41) | ADRB2KCNH2HTR2A | |
| SCHEMBL9764694 | 0.85 | NR1H3 (0.45) | ADRB2NPC1KCNH2ALDH1A1 | |
| SCHEMBL9764542 | 0.84 | ADRB2 (0.41) | ADRB2KCNH2ALDH1A1LMNA | |
| SCHEMBL9764425 | 0.83 | KCNH2 (0.51) | ADRB2KCNH2 | |
| SCHEMBL9321535 | 0.82 | MAOB (0.37) | ADRB2LMNAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006556-A | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction | GLAXO GROUP LIMITED (GB) | 1991-04-09 | — | — | US | disclosed |
| US-4943591-A | TREATMENT OF ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |
| EP-0181709-A1 | Dichloroaniline Derivatives | GLAXO GROUP LIMITED (GB) | 1986-05-21 | — | — | EP | disclosed |