Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 5/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764456 | 0.89 | ADRB2 (0.41) | ADRB2KCNH2SLC2A1NR1H3MAOB | |
| SCHEMBL9764429 | 0.89 | ADRB2 (0.41) | ADRB2KCNH2SLC2A1NR1H3MAOB | |
| SCHEMBL9764425 | 0.88 | KCNH2 (0.51) | ADRB2KCNH2 | |
| SCHEMBL9764389 | 0.87 | ADRB2 (0.39) | ADRB2KCNH2SLC2A1NR1H3MAPT | |
| SCHEMBL9764694 | 0.86 | NR1H3 (0.45) | ADRB2KCNH2NR1H3MAOBALDH1A1 | |
| SCHEMBL9764329 | 0.86 | ADRB2 (0.39) | ADRB2SLC2A1NR1H3 | |
| SCHEMBL9764371 | 0.85 | ADRB2 (0.41) | ADRB2KCNH2SLC2A1NR1H3 | |
| SCHEMBL9764242 | 0.84 | MC4R (0.39) | ADRB2KCNH2ALDH1A1LMNA | |
| SCHEMBL9764460 | 0.83 | LTB4R (0.38) | ADRB2SLC2A1NR1H3ALDH1A1 | |
| SCHEMBL9321535 | 0.83 | MAOB (0.37) | ADRB2NR1H3MAOBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006556-A | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction | GLAXO GROUP LIMITED (GB) | 1991-04-09 | — | — | US | disclosed |
| US-4943591-A | TREATMENT OF ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |
| EP-0181709-B1 | DICHLOROANILINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1990-05-09 | — | — | EP | disclosed |
| EP-0181709-A1 | Dichloroaniline Derivatives | GLAXO GROUP LIMITED (GB) | 1986-05-21 | — | — | EP | disclosed |