Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 8/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4515850 | 0.93 | ADRB1 (0.44) | ADRB1CHRM2CHRM1HTR3AHTR6 | |
| SCHEMBL1385232 | 0.85 | CHKA (0.32) | MEN1KMT2ATDP1 | |
| SCHEMBL6751496 | 0.83 | ALDH1A1 (0.33) | MEN1KMT2ATDP1HRH3 | |
| SCHEMBL11053972 | 0.80 | — | — | |
| SCHEMBL15421672 | 0.74 | MEN1 (0.30) | CXCR4MEN1CHRM2CHRM1ADRA2C | |
| SCHEMBL8410646 | 0.72 | LMNA (0.41) | MEN1KMT2A | |
| SCHEMBL5829529 | 0.69 | CHRNB2 (0.45) | CHRNB2CHRNA4ADRB1CXCR4TDP1 | |
| SCHEMBL215813 | 0.67 | ADRB1 (0.53) | CHRNB2CHRNA4ADRB1HTR3ACHRNA1 | |
| SCHEMBL82301 | 0.67 | ADRB1 (0.85) | CHRNB2CHRNA4ADRB1CXCR4HTR3A | |
| SCHEMBL3066756 | 0.66 | ADRB1 (0.83) | CHRNB2CHRNA4ADRB1HTR3AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |