Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764632 | 1.00 | DRD2 (0.47) | DRD2DRD3DRD4MAOANPC1 | |
| SCHEMBL9763725 | 0.81 | DRD2 (0.51) | DRD2DRD3DRD4MAOANPC1 | |
| SCHEMBL9763382 | 0.80 | NPC1 (0.43) | NPC1HPGDRAB9ASMN1; SMN2ALOX5 | |
| SCHEMBL9762521 | 0.80 | NPC1 (0.43) | NPC1ARHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9762517 | 0.80 | NPC1 (0.43) | NPC1ARHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9763377 | 0.80 | NPC1 (0.43) | NPC1HPGDRAB9ASMN1; SMN2ALOX5 | |
| SCHEMBL9763494 | 0.77 | DRD2 (0.47) | DRD2DRD3DRD4MAOANPC1 | |
| SCHEMBL10478066 | 0.76 | ADRB2 (0.49) | SMN1; SMN2ADRB2ADRB1ADRB3 | |
| SCHEMBL10478060 | 0.76 | ADRB2 (0.49) | SMN1; SMN2ADRB2ADRB1ADRB3 | |
| SCHEMBL7907015 | 0.75 | SIGMAR1 (0.64) | DRD2DRD3DRD4MAOANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006556-A | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction | GLAXO GROUP LIMITED (GB) | 1991-04-09 | — | — | US | disclosed |
| US-4943591-A | TREATMENT OF ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |