Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.62 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.52 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764581 | 0.82 | FAAH (0.46) | TRPA1F10F2 | |
| SCHEMBL11290693 | 0.82 | F10 (0.50) | ALOX5F10F2 | |
| SCHEMBL6370572 | 0.81 | GPR84 (0.51) | TRPA1TRPV1 | |
| SCHEMBL20966571 | 0.81 | GPR84 (0.51) | TRPA1TRPV1 | |
| SCHEMBL22033713 | 0.81 | GPR84 (0.51) | TRPA1TRPV1 | |
| SCHEMBL31674543 | 0.81 | GPR84 (0.51) | TRPA1TRPV1 | |
| SCHEMBL15710472 | 0.81 | GPR84 (0.51) | TRPA1TRPV1 | |
| SCHEMBL6370981 | 0.81 | GPR84 (0.51) | TRPA1TRPV1 | |
| SCHEMBL16320515 | 0.81 | TRPA1 (0.74) | TRPA1TRPV1 | |
| SCHEMBL9772153 | 0.80 | SIRT2 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5041694-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1991-08-20 | — | — | US | disclosed |
| US-4965373-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1990-10-23 | — | — | US | disclosed |
| US-4895973-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & COMPANY (US) | 1990-01-23 | — | — | US | disclosed |
| EP-0194610-B1 | SUBSTITUTED GLUTARIC ACID LACTONES IN THE TREATMENT OF HYPERLIPIDEMIA | G.D. Searle & Co. (US) | 1989-02-22 | — | — | EP | disclosed |
| US-4622338-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1986-11-11 | — | — | US | disclosed |
| EP-0194610-A1 | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G.D. Searle & Co. (US) | 1986-09-17 | — | — | EP | disclosed |