Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828002 | 0.83 | ALDH1A1 (0.48) | ALDH1A1TSHRKDM4EF2NPC1 | |
| SCHEMBL9764628 | 0.82 | TRPA1 (0.62) | F2TRPA1F10 | |
| SCHEMBL7708867 | 0.81 | CYP3A4 (0.53) | ALDH1A1TSHRKDM4ENPC1HPGD | |
| SCHEMBL23027267 | 0.81 | LTB4R (0.54) | ALDH1A1TSHRKDM4EF2NPC1 | |
| SCHEMBL563306 | 0.81 | LTB4R (0.54) | ALDH1A1TSHRKDM4EF2NPC1 | |
| SCHEMBL13572924 | 0.81 | LTB4R (0.54) | ALDH1A1TSHRKDM4EF2NPC1 | |
| SCHEMBL14462418 | 0.79 | RIPK1 (0.50) | KDM4ETRPA1 | |
| SCHEMBL29069352 | 0.78 | ALDH1A1 (0.52) | ALDH1A1TSHRKDM4ENPC1HPGD | |
| SCHEMBL10368115 | 0.78 | ALDH1A1 (0.44) | ALDH1A1TSHRKDM4ENPC1HPGD | |
| SCHEMBL22677576 | 0.78 | GPR84 (0.46) | FAAHALDH1A1KMT2ATRPA1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5041694-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1991-08-20 | — | — | US | claimed |
| US-5041694-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1991-08-20 | — | — | US | disclosed |
| US-4965373-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1990-10-23 | — | — | US | disclosed |
| US-4895973-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & COMPANY (US) | 1990-01-23 | — | — | US | disclosed |
| EP-0194610-B1 | SUBSTITUTED GLUTARIC ACID LACTONES IN THE TREATMENT OF HYPERLIPIDEMIA | G.D. Searle & Co. (US) | 1989-02-22 | — | — | EP | disclosed |
| US-4622338-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1986-11-11 | — | — | US | disclosed |
| EP-0194610-A1 | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G.D. Searle & Co. (US) | 1986-09-17 | — | — | EP | disclosed |