Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | CNR2 | P34972 | 7/20 | 0.47 |
| ▸ | RORC | P51449 | 3/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | RORA | P35398 | 2/20 | 0.44 |
| ▸ | RORB | Q92753 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764967 | 0.83 | POLB (0.51) | ALDH1A1HPGDPOLBKDM4ELMNA | |
| SCHEMBL9764822 | 0.82 | POLB (0.46) | ALDH1A1HPGDPOLBKDM4ELMNA | |
| SCHEMBL9764927 | 0.79 | P2RX4 (0.47) | ALDH1A1HPGDPOLBKDM4ELMNA | |
| SCHEMBL28266234 | 0.76 | NPC1 (0.80) | ALDH1A1HPGDKDM4ELMNAMAPT | |
| SCHEMBL29643244 | 0.76 | NPC1 (0.80) | ALDH1A1HPGDKDM4ELMNAMAPT | |
| SCHEMBL31694997 | 0.76 | ALDH1A1 (0.55) | ALDH1A1HPGDPOLBKDM4ELMNA | |
| SCHEMBL5807330 | 0.76 | PGR (0.63) | ALDH1A1HPGDPOLBKDM4ELMNA | |
| SCHEMBL16093698 | 0.73 | ALDH1A1 (0.58) | ALDH1A1HPGDPOLBKDM4ELMNA | |
| SCHEMBL14280393 | 0.72 | ALDH1A1 (0.53) | ALDH1A1HPGDPOLBKDM4ELMNA | |
| SCHEMBL4725593 | 0.72 | KDM4E (0.74) | ALDH1A1HPGDPOLBKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |