Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764866 | 0.81 | ALOX5 (0.43) | ALOX5CYP1A2ALDH1A1MAPTHPGD | |
| SCHEMBL9764833 | 0.81 | ALOX5 (0.43) | ALOX5CYP1A2ALDH1A1MAPTHPGD | |
| SCHEMBL9764814 | 0.78 | ALOX5 (0.45) | ALOX5GPR3IKBKBLIMK1 | |
| SCHEMBL9764904 | 0.76 | ALOX5 (0.49) | ALOX5CYP1A2ALDH1A1MAPTHPGD | |
| SCHEMBL10559630 | 0.76 | ALOX5 (0.42) | ALOX5CYP1A2ALDH1A1MAPTHPGD | |
| SCHEMBL10559925 | 0.70 | ALOX5 (0.57) | ALOX5CYP1A2ALOX15LMNAALOX12 | |
| SCHEMBL9764852 | 0.70 | PLA2G10 (0.40) | ALOX5 | |
| SCHEMBL3877060 | 0.69 | GPR3 (0.61) | ALOX5CYP1A2ALDH1A1MAPTHPGD | |
| Urea SCHEMBL9764918 | 0.69 | ALOX5 (0.56) | ALOX5CYP1A2ALOX15LMNAALOX12 | |
| SCHEMBL436458 | 0.69 | CYP2A6 (0.51) | ALOX5CYP1A2ALOX15LMNAALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |