Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9157244 | 0.77 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL1775541 | 0.73 | ATM (0.46) | KDM4EALDH1A1HSD17B10HPGDTHRB | |
| SCHEMBL8367148 | 0.73 | AKR1C3 (0.49) | KDM4EALDH1A1HSD17B10HPGDTHRB | |
| SCHEMBL28977348 | 0.73 | CXCL8 (0.39) | CXCL8PTGS2PTGS1ABCB11PPARG | |
| SCHEMBL9157813 | 0.71 | HPGD (0.48) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL1800554 | 0.70 | TRPA1 (0.51) | — | |
| SCHEMBL8578245 | 0.69 | AKR1C3 (0.48) | KDM4EALDH1A1CXCL8PTGS2THRB | |
| SCHEMBL9766045 | 0.69 | MEN1 (0.51) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL9766040 | 0.69 | GRIN2D (0.47) | KDM4EALDH1A1CXCL8GAATHRB | |
| SCHEMBL17929744 | 0.69 | ALDH1A1 (0.57) | ALDH1A1HSD17B10MAPTPOLBCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4983607-A | ANTISEROTONINERGIC ACTIVITY | SYNTHELABO (FR) | 1991-01-08 | — | — | US | disclosed |