SCHEMBL9767582

SCHEMBL9767582

C=CC(c1ccccc1)C(F)(F)C(=C)O[Si](C)(C)C.C=CC(c1ccccc1)C(F)(F)C(=O)[Si](C)(C)C

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.33
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9776384 0.91 ALDH1A1 (0.31)
SCHEMBL9767783 0.88 LMNA (0.39) LMNAHPGD
SCHEMBL9776466 0.72 HPGD (0.40) LMNAHPGD
SCHEMBL9776400 0.64 FAAH (0.43)
SCHEMBL10415149 0.63 HTR2A (0.36) LMNA
SCHEMBL9776328 0.62 LMNA (0.37) LMNAHPGD
SCHEMBL18083240 0.61 HSP90AA1 (0.37) LMNA
SCHEMBL27988263 0.61 RIPK1 (0.41) LMNAHPGD
SCHEMBL6841869 0.60 RIPK1 (0.39) LMNAHPGD
SCHEMBL7903887 0.59 CYP2C19 (0.37) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5057626-A Difluoroketones from difluoroacylsilanes PFIZER INC. (US) 1991-10-15 US disclosed