Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | ACP3 | P15309 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9767582 | 0.88 | LMNA (0.33) | LMNAHPGD | |
| SCHEMBL9776466 | 0.82 | HPGD (0.40) | LMNACYP2C19HPGDKMT2AMEN1 | |
| SCHEMBL9776384 | 0.76 | ALDH1A1 (0.31) | — | |
| SCHEMBL9776400 | 0.73 | FAAH (0.43) | KMT2AMEN1 | |
| SCHEMBL10415149 | 0.72 | HTR2A (0.36) | LMNACYP2C19SMN1; SMN2ACP3 | |
| SCHEMBL9776328 | 0.70 | LMNA (0.37) | LMNACYP2C19HPGDKMT2AMEN1 | |
| SCHEMBL18083240 | 0.69 | HSP90AA1 (0.37) | LMNACYP2C19KMT2AMEN1PTPN1 | |
| SCHEMBL27988263 | 0.69 | RIPK1 (0.41) | LMNACYP2C19HPGD | |
| SCHEMBL6841869 | 0.68 | RIPK1 (0.39) | LMNACYP2C19HPGD | |
| SCHEMBL9196490 | 0.66 | SRC (0.41) | LMNACYP2C19HPGDPTPN1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057626-A | Difluoroketones from difluoroacylsilanes | PFIZER INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4996345-A | Difluoroketones from difluoroacylsilanes | PFIZER INC. (US) | 1991-02-26 | — | — | US | disclosed |