Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL475134 | 0.75 | — | — | |
| SCHEMBL5151350 | 0.75 | — | — | |
| SCHEMBL1862113 | 0.73 | — | — | |
| SCHEMBL7827896 | 0.73 | — | — | |
| SCHEMBL11847069 | 0.70 | — | — | |
| SCHEMBL10628101 | 0.70 | LMNA (0.50) | — | |
| SCHEMBL10634526 | 0.70 | LMNA (0.44) | — | |
| SCHEMBL2657617 | 0.68 | — | — | |
| SCHEMBL9194192 | 0.68 | ALDH1A1 (0.41) | — | |
| SCHEMBL10687453 | 0.67 | ALDH1A1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5059601-A | IMIDAZOLONE DERIVATIVES WITH ACTIVITY ON CENTRAL NERVOUS SYSTEM AND ANTIHYPERTENSIVE ACTIVITY, PREPARATION METHODS THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ISTITUTO LUSOFARMACO D'ITALIA S.P.A. (IT) | 1991-10-22 | — | — | US | disclosed |
| EP-0379990-A1 | Imidazolone derivatives with activity on central nervous system and antihypertensive activity, preparation methods thereof, and pharmaceutical compositions containing them | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1990-08-01 | — | — | EP | disclosed |