Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28439394 | 0.83 | LMNA (0.54) | LMNAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL20870240 | 0.73 | PDE9A (0.56) | ALDH1A1HSD17B10CASP1NPSR1KDM4E | |
| SCHEMBL9770634 | 0.71 | LMNA (0.53) | LMNAALDH1A1HSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL8873183 | 0.70 | GRIN2D (0.77) | LMNAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL25394868 | 0.70 | GRIN2D (0.62) | LMNAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL30099670 | 0.69 | DGKA (0.53) | LMNAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL23579065 | 0.69 | DGKA (0.53) | LMNAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1054236 | 0.68 | FGFR1 (0.64) | LMNAALDH1A1POLBNPSR1KDM4E | |
| SCHEMBL5168397 | 0.68 | CTSB (0.62) | LMNAALDH1A1POLBNPSR1SMN1; SMN2 | |
| SCHEMBL9770560 | 0.68 | ALDH1A1 (0.54) | LMNAALDH1A1HSD17B10NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5019574-A | 3,4-diaminoquinoline and 3,4-diamino-5,6,7,8-tetrahydroquinoline compounds useful for improving psychoneural function | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1991-05-28 | — | — | US | disclosed |
| EP-0361489-A2 | Novel 3,4-diaminoquinoline and pyridine compounds | Chugai Seiyaku Kabushiki Kaisha (JP) | 1990-04-04 | — | — | EP | disclosed |