Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2871139 | 1.00 | CES2 (0.44) | CES2CES1KEAP1KDM4EALOX5 | |
| SCHEMBL2871143 | 1.00 | CES2 (0.44) | CES2CES1KEAP1KDM4EALOX5 | |
| SCHEMBL28814772 | 0.85 | ALOX5 (0.45) | CES2CES1KEAP1KDM4EALOX5 | |
| SCHEMBL29065807 | 0.85 | ALOX5 (0.45) | CES2CES1KEAP1KDM4EALOX5 | |
| SCHEMBL29065809 | 0.85 | ALOX5 (0.45) | CES2CES1KEAP1KDM4EALOX5 | |
| SCHEMBL2859012 | 0.84 | ALDH1A1 (0.43) | CES2CES1KEAP1KDM4EALOX5 | |
| SCHEMBL2874009 | 0.84 | TSHR (0.42) | CES2CES1KEAP1KDM4EALOX5 | |
| SCHEMBL2866024 | 0.84 | TSHR (0.42) | CES2CES1KEAP1KDM4EALOX5 | |
| SCHEMBL2859011 | 0.84 | ALDH1A1 (0.43) | CES2CES1KEAP1KDM4EALOX5 | |
| SCHEMBL2867866 | 0.84 | ALDH1A1 (0.43) | CES2CES1KEAP1KDM4EALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1405917-B1 | Process for the production of 3-Heteroaryl-3-hydroxy-propionic acid derivatives by enantioselective microbial reduction | SALTIGO GMBH (DE) | 2013-08-14 | — | — | EP | claimed |
| EP-1405917-A2 | Process for the production of 3-Heteroaryl-3-hydroxy-propionic acid derivatives by enantioselective microbial reduction | Bayer Chemicals AG (DE) | 2004-04-07 | — | — | EP | claimed |
| US-20140357874-A1 | PROCESS FOR PREPARING (S)-3-N-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL | SALTIGO GMBH (DE) | 2014-12-04 | — | — | US | disclosed |
| US-20140031564-A1 | PROCESS FOR PREPARING (S)-3-N-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL | SALTIGO GMBH (DE) | 2014-01-30 | — | — | US | disclosed |
| EP-1405917-B1 | Process for the production of 3-Heteroaryl-3-hydroxy-propionic acid derivatives by enantioselective microbial reduction | SALTIGO GMBH (DE) | 2013-08-14 | — | — | EP | disclosed |
| EP-2426116-B1 | Method for producing (S)-3-N-Methylamino-1-(2-thienyl)-1-propanol | SALTIGO GMBH (DE) | 2013-06-26 | — | — | EP | disclosed |
| EP-2426116-A1 | Method for producing (S)-3-N-Methylamino-1-(2-thienyl)-1-propanol | Saltigo GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |
| US-7893281-B2 | Process for preparing arylaminopropanols | LANXESS DEUTSCHLAND GMBH (DE) | 2011-02-22 | — | — | US | disclosed |
| US-7893281-B2 | Process for preparing arylaminopropanols | LANXESS DEUTSCHLAND GMBH (DE) | 2011-02-22 | — | — | US | disclosed |
| US-7893281-B2 | Process for preparing arylaminopropanols | LANXESS DEUTSCHLAND GMBH (DE) | 2011-02-22 | — | — | US | disclosed |
| US-7659409-B2 | 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2010-02-09 | — | — | US | disclosed |
| US-20080262247-A1 | Process for preparing arylaminopropanols | ECKERT MARKUS | 2008-10-23 | — | — | US | disclosed |
| US-20080262247-A1 | Process for preparing arylaminopropanols | ECKERT MARKUS | 2008-10-23 | — | — | US | disclosed |
| EP-1340746-B1 | Process for the reduction of 3-heteroaryl-3-oxo-propanoic acid derivatives | SALTIGO GMBH (DE) | 2007-02-28 | — | — | EP | disclosed |
| US-7169938-B2 | Process for preparing arylaminopropanols | LANXESS DEUTSCHLAND GMBH (DE) | 2007-01-30 | — | — | US | disclosed |
| US-7169938-B2 | Process for preparing arylaminopropanols | LANXESS DEUTSCHLAND GMBH (DE) | 2007-01-30 | — | — | US | disclosed |
| US-20050107621-A1 | 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2005-05-19 | — | — | US | disclosed |
| EP-1486493-A1 | 3-HYDROXY-3-(2-THIENYL)PROPIONAMIDE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING 3-AMINO-1-(2-THIENYL)-1-PROPANOL COMPOUND THEREFROM | Mitsubishi Chemical Corporation (JP) | 2004-12-15 | — | — | EP | disclosed |
| EP-1405917-A2 | Process for the production of 3-Heteroaryl-3-hydroxy-propionic acid derivatives by enantioselective microbial reduction | Bayer Chemicals AG (DE) | 2004-04-07 | — | — | EP | disclosed |
| EP-1340746-A1 | Process for the reduction of 3-heteroaryl-3-oxo-propanoic acid derivatives | BAYER AG (DE) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107621-A1 | 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same | APEH, AADAC, KMO | CES2 719/4885CES1 126/4885KEAP1 2855/4885 |
| US-20140357874-A1 | PROCESS FOR PREPARING (S)-3-N-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL | PNMT, SULT1A1, CYP51A1 | CES2 1944/4885CES1 529/4885KEAP1 3337/4885 |
| US-20140031564-A1 | PROCESS FOR PREPARING (S)-3-N-METHYLAMINO-1-(2-THIENYL)-1-PROPANOL | PNMT, SULT1A1, CYP51A1 | CES2 1944/4885CES1 529/4885KEAP1 3337/4885 |
| US-20080262247-A1 | Process for preparing arylaminopropanols | CYP1A1, CYP1A2, AHR | CES2 127/4885CES1 723/4885KEAP1 961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.