Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1551331 | 0.87 | CYP4F2 (0.59) | CYP4F2CYP4A11ALDH1A1KDM4ELMNA | |
| SCHEMBL6068538 | 0.85 | ALDH1A1 (0.59) | CYP4F2CYP4A11ALDH1A1KDM4ELMNA | |
| SCHEMBL10695731 | 0.82 | MMP12 (0.45) | ALDH1A1KDM4ELMNATSHRHSD17B10 | |
| SCHEMBL5802908 | 0.80 | CA2 (0.50) | CYP4F2CYP4A11ALDH1A1KDM4ELMNA | |
| SCHEMBL6795893 | 0.80 | TDP1 (0.50) | CYP4F2CYP4A11ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10140460 | 0.80 | CYP4F2 (0.50) | CYP4F2CYP4A11ALDH1A1KDM4ELMNA | |
| SCHEMBL10829361 | 0.79 | CYP4F2 (0.49) | CYP4F2CYP4A11ALDH1A1KDM4ELMNA | |
| SCHEMBL6025472 | 0.79 | ALDH1A1 (0.56) | CYP4F2CYP4A11ALDH1A1LMNATSHR | |
| SCHEMBL754043 | 0.79 | KMT2A (0.51) | CYP4F2CYP4A11KDM4ELMNASMN1; SMN2 | |
| SCHEMBL27348043 | 0.79 | LOXL2 (0.55) | CYP4F2CYP4A11ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990526-A | Skin disorders, antiallergens, antiinflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1991-02-05 | — | — | US | disclosed |
| EP-0206741-A2 | Leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1986-12-30 | — | — | EP | disclosed |