Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | RPS6KB2 | Q9UBS0 | 4/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20392667 | 0.81 | ADORA2A (0.53) | DHFRADORA2AMEN1KMT2AALDH1A1 | |
| SCHEMBL23931338 | 0.76 | MEN1 (0.50) | DHFRADORA2AMEN1KMT2AALDH1A1 | |
| SCHEMBL10456321 | 0.74 | DHFR (0.85) | DHFRCSNK1A1CLK4ADORA2AMEN1 | |
| SCHEMBL978843 | 0.72 | MAPT (0.56) | CSNK1A1CLK4ADORA2AMEN1KMT2A | |
| SCHEMBL7243836 | 0.70 | RPS6KB2 (0.56) | DHFRADORA2AMEN1KMT2AALDH1A1 | |
| SCHEMBL978238 | 0.70 | APP (0.50) | CSNK1A1CLK4ADORA2ACYP2D6PLAU | |
| SCHEMBL976587 | 0.70 | CYP2D6 (0.46) | CSNK1A1CLK4ADORA2AMEN1KMT2A | |
| SCHEMBL976591 | 0.70 | CSNK1A1 (0.46) | DHFRCSNK1A1CLK4ADORA2AMEN1 | |
| SCHEMBL820251 | 0.70 | RPS6KB2 (0.50) | DHFRADORA2AMEN1KMT2AALDH1A1 | |
| SCHEMBL976667 | 0.69 | CSNK1A1 (1.00) | DHFRCSNK1A1CLK4ADORA2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230165869-A1 | DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME | UNIVERSITY OF GREENWICH (GB) | 2023-06-01 | — | — | US | claimed |
| US-20230167075-A1 | INTERLEUKIN INHIBITORS | UNIVERSITY OF GREENWICH (GB) | 2023-06-01 | — | — | US | claimed |
| EP-4138839-A1 | DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME | University of Greenwich (GB) | 2023-03-01 | — | — | EP | claimed |
| EP-4138838-A1 | INTERLEUKIN INHIBITORS | University of Greenwich (GB) | 2023-03-01 | — | — | EP | claimed |
| WO-2021214494-A1 | INTERLEUKIN INHIBITORS | UNIVERSITY OF GREENWICH (GB) | 2021-10-28 | — | — | WO | claimed |
| WO-2021214495-A1 | DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME | UNIVERSITY OF GREENWICH (GB) | 2021-10-28 | — | — | WO | claimed |
| EP-3002280-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | University of Greenwich (GB) | 2016-04-06 | — | — | EP | claimed |
| US-20140155403-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIVERSITY OF GREENWICH (GB) | 2014-06-05 | — | — | US | claimed |
| US-20230165869-A1 | DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME | UNIVERSITY OF GREENWICH (GB) | 2023-06-01 | — | — | US | disclosed |
| US-20230167075-A1 | INTERLEUKIN INHIBITORS | UNIVERSITY OF GREENWICH (GB) | 2023-06-01 | — | — | US | disclosed |
| EP-3002280-B1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIV GREENWICH (GB) | 2023-05-24 | — | — | EP | disclosed |
| EP-4138838-A1 | INTERLEUKIN INHIBITORS | University of Greenwich (GB) | 2023-03-01 | — | — | EP | disclosed |
| EP-4138839-A1 | DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME | University of Greenwich (GB) | 2023-03-01 | — | — | EP | disclosed |
| WO-2021214495-A1 | DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME | UNIVERSITY OF GREENWICH (GB) | 2021-10-28 | — | — | WO | disclosed |
| US-20140155403-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIVERSITY OF GREENWICH (GB) | 2014-06-05 | — | — | US | disclosed |
| CN-101918378-B | Cyclic azide and sodium diazoxide channel blockers | UNIV GREENWICH | 2013-12-04 | — | — | CN | disclosed |
| US-20110009413-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIVERSITY OF GREENWICH (GB) | 2011-01-13 | — | — | US | disclosed |
| CN-101918378-A | Cyclic azide and sodium diazoxide channel blockers | UNIV GREENWICH | 2010-12-15 | — | — | CN | disclosed |
| EP-2229371-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | University of Greenwich (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009090431-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIVERSITY OF GREENWICH (GB) | 2009-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155403-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | SCN1A, SCN1B, SCN3A | DHFR 1243/4885CSNK1A1 719/4885CLK4 1935/4885 |
| US-20110009413-A1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | CACNA1E, SCN2B, SCN3A | DHFR 896/4885CSNK1A1 4578/4885CLK4 4586/4885 |
| US-20230167075-A1 | INTERLEUKIN INHIBITORS | IL2, IL1A, IL1B | DHFR 1900/4885CSNK1A1 2589/4885CLK4 3139/4885 |
| US-20230165869-A1 | DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME | IFNG, TNF, IL1A | DHFR 1366/4885CSNK1A1 2546/4885CLK4 2060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.