Sugi Predict

Sugi Predict / Compounds / SCHEMBL976591

SCHEMBL976591

SCHEMBL976591

Nc1nnc(-c2sccc2Br)c(N)n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CSNK1A1 P48729 1/20 0.46
▸ CLK4 Q9HAZ1 1/20 0.46
▸ CYP2D6 P10635 1/20 0.42
▸ MAOA P21397 1/20 0.42
▸ MAPK1 P28482 1/20 0.42
▸ ADRA1A P35348 1/20 0.42
▸ SCN4A P35499 1/20 0.42
▸ BLM P54132 1/20 0.42
▸ PMP22 Q01453 1/20 0.42
▸ PDE3A Q14432 1/20 0.42
▸ SCN5A Q14524 1/20 0.42
▸ SCN9A Q15858 1/20 0.42
▸ SCN2A Q99250 1/20 0.42
▸ SCN3A Q9NY46 1/20 0.42
▸ SCN10A Q9Y5Y9 1/20 0.42
▸ POLB P06746 2/20 0.37
▸ MAPT P10636 3/20 0.35
▸ RXFP1 Q9HBX9 3/20 0.35
▸ NPC1 O15118 2/20 0.35
▸ RAB9A P51151 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23931370 0.76 SCN2A (0.36) SCN2APOLBMAPTRXFP1NPC1
SCHEMBL977030 0.73 CSNK1A1 (0.56) CSNK1A1CLK4CYP2D6MAOAMAPK1
SCHEMBL23931362 0.72 FGFR1 (0.43) POLBDHFR
SCHEMBL23931350 0.72 CYP2A6 (0.36) POLBMAPTRXFP1NPC1RAB9A
SCHEMBL978698 0.70 DHFR (0.56) CSNK1A1CLK4CYP2D6MAOAMAPK1
SCHEMBL978843 0.69 MAPT (0.56) CSNK1A1CLK4CYP2D6MAOAMAPK1
SCHEMBL770898 0.68 POLB (0.44) POLBMAPTRXFP1NPC1RAB9A
SCHEMBL11067545 0.68 CYP2D6 (0.50) CSNK1A1CLK4CYP2D6MAOAMAPK1
SCHEMBL30723293 0.67 POLB (0.58) CYP2D6POLBMAPTRXFP1NPC1
SCHEMBL976592 0.67 CSNK1A1 (0.41) CSNK1A1CLK4CYP2D6MAOAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230165869-A1 DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME UNIVERSITY OF GREENWICH (GB) 2023-06-01 — — US claimed
US-20230167075-A1 INTERLEUKIN INHIBITORS UNIVERSITY OF GREENWICH (GB) 2023-06-01 — — US claimed
EP-4138839-A1 DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME University of Greenwich (GB) 2023-03-01 — — EP claimed
EP-4138838-A1 INTERLEUKIN INHIBITORS University of Greenwich (GB) 2023-03-01 — — EP claimed
CN-107921046-B Triazine derivatives as interferon-gamma inhibitors 格林威治大学 2022-10-14 — — CN claimed
WO-2021214495-A1 DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME UNIVERSITY OF GREENWICH (GB) 2021-10-28 — — WO claimed
WO-2021214494-A1 INTERLEUKIN INHIBITORS UNIVERSITY OF GREENWICH (GB) 2021-10-28 — — WO claimed
EP-3307273-B1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIV GREENWICH (GB) 2020-12-09 — — EP claimed
US-10576086-B2 Triazine derivatives as interferon-gamma inhibitors UNIVERSITY OF GREENWICH (GB) 2020-03-03 — — US claimed
US-20180169105-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIVERSITY OF GREENWICH (GB) 2018-06-21 — — US claimed
EP-3307273-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS University of Greenwich (GB) 2018-04-18 — — EP claimed
WO-2016198878-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIVERSITY OF GREENWICH (GB) 2016-12-15 — — WO claimed
US-9422253-B2 Cyclic triazo and diazo sodium channel blockers UNIVERSITY OF GREENWICH (GB) 2016-08-23 — — US claimed
EP-3002280-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS University of Greenwich (GB) 2016-04-06 — — EP claimed
US-20140155403-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2014-06-05 — — US claimed
US-20230165869-A1 DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME UNIVERSITY OF GREENWICH (GB) 2023-06-01 — — US disclosed
US-20230167075-A1 INTERLEUKIN INHIBITORS UNIVERSITY OF GREENWICH (GB) 2023-06-01 — — US disclosed
US-20110009413-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2011-01-13 — — US disclosed
EP-2229371-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS University of Greenwich (GB) 2010-09-22 — — EP disclosed
WO-2009090431-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2009-07-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140155403-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS SCN1A, SCN1B, SCN3A CSNK1A1 719/4885CLK4 1935/4885CYP2D6 1326/4885
US-20110009413-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS CACNA1E, SCN2B, SCN3A CSNK1A1 4578/4885CLK4 4586/4885CYP2D6 3472/4885
US-20230167075-A1 INTERLEUKIN INHIBITORS IL2, IL1A, IL1B CSNK1A1 2589/4885CLK4 3139/4885CYP2D6 276/4885
US-20230165869-A1 DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME IFNG, TNF, IL1A CSNK1A1 2546/4885CLK4 2060/4885CYP2D6 2190/4885
US-10576086-B2 Triazine derivatives as interferon-gamma inhibitors IFNG, IFNAR1, IRF3 CSNK1A1 599/4885CLK4 3082/4885CYP2D6 1766/4885
US-20180169105-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS IFNG, IFNAR1, IRF3 CSNK1A1 599/4885CLK4 3082/4885CYP2D6 1766/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.