Sugi Predict

Sugi Predict / Compounds / SCHEMBL978843

SCHEMBL978843

SCHEMBL978843

Nc1nnc(-c2ccc(Br)s2)c(N)n1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.56
▸ MEN1 O00255 4/20 0.56
▸ KMT2A Q03164 4/20 0.56
▸ HSD17B10 Q99714 2/20 0.56
▸ ALOX12 P18054 2/20 0.56
▸ ALOX15 P16050 1/20 0.56
▸ CSNK1A1 P48729 1/20 0.47
▸ CLK4 Q9HAZ1 1/20 0.47
▸ CYP2D6 P10635 1/20 0.40
▸ MAOA P21397 1/20 0.40
▸ MAPK1 P28482 1/20 0.40
▸ ADRA1A P35348 1/20 0.40
▸ SCN4A P35499 1/20 0.40
▸ BLM P54132 1/20 0.40
▸ PMP22 Q01453 1/20 0.40
▸ PDE3A Q14432 1/20 0.40
▸ SCN5A Q14524 1/20 0.40
▸ SCN9A Q15858 1/20 0.40
▸ SCN2A Q99250 1/20 0.40
▸ SCN3A Q9NY46 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL976587 0.80 CYP2D6 (0.46) MAPTMEN1KMT2AHSD17B10ALOX12
SCHEMBL976592 0.75 CSNK1A1 (0.41) MAPTMEN1KMT2AHSD17B10ALOX12
SCHEMBL23931365 0.74 MAPT (0.56) MAPTMEN1KMT2AHSD17B10ALOX12
SCHEMBL978698 0.72 DHFR (0.56) MAPTMEN1KMT2AHSD17B10CSNK1A1
SCHEMBL4011780 0.71 MAPT (0.52) MAPTMEN1KMT2AHSD17B10ALOX12
SCHEMBL23931378 0.70 MAPT (0.56) MAPTMEN1KMT2AHSD17B10ALOX12
SCHEMBL978238 0.69 APP (0.50) CSNK1A1CLK4CYP2D6MAOAMAPK1
SCHEMBL23931352 0.69 MAPT (0.46) MAPTMEN1KMT2AHSD17B10ALOX12
SCHEMBL976591 0.69 CSNK1A1 (0.46) MAPTMEN1KMT2ACSNK1A1CLK4
SCHEMBL197157 0.67 SNCA (0.50) MAPTMEN1KMT2AHSD17B10ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230165869-A1 DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME UNIVERSITY OF GREENWICH (GB) 2023-06-01 — — US claimed
US-20230167075-A1 INTERLEUKIN INHIBITORS UNIVERSITY OF GREENWICH (GB) 2023-06-01 — — US claimed
EP-4138839-A1 DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME University of Greenwich (GB) 2023-03-01 — — EP claimed
EP-4138838-A1 INTERLEUKIN INHIBITORS University of Greenwich (GB) 2023-03-01 — — EP claimed
CN-107921046-B Triazine derivatives as interferon-gamma inhibitors 格林威治大学 2022-10-14 — — CN claimed
WO-2021214495-A1 DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME UNIVERSITY OF GREENWICH (GB) 2021-10-28 — — WO claimed
WO-2021214494-A1 INTERLEUKIN INHIBITORS UNIVERSITY OF GREENWICH (GB) 2021-10-28 — — WO claimed
EP-3307273-B1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIV GREENWICH (GB) 2020-12-09 — — EP claimed
US-10576086-B2 Triazine derivatives as interferon-gamma inhibitors UNIVERSITY OF GREENWICH (GB) 2020-03-03 — — US claimed
US-20180169105-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIVERSITY OF GREENWICH (GB) 2018-06-21 — — US claimed
EP-3307273-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS University of Greenwich (GB) 2018-04-18 — — EP claimed
WO-2016198878-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS UNIVERSITY OF GREENWICH (GB) 2016-12-15 — — WO claimed
US-9422253-B2 Cyclic triazo and diazo sodium channel blockers UNIVERSITY OF GREENWICH (GB) 2016-08-23 — — US claimed
EP-3002280-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS University of Greenwich (GB) 2016-04-06 — — EP claimed
US-20140155403-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2014-06-05 — — US claimed
US-20230165869-A1 DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME UNIVERSITY OF GREENWICH (GB) 2023-06-01 — — US disclosed
US-20230167075-A1 INTERLEUKIN INHIBITORS UNIVERSITY OF GREENWICH (GB) 2023-06-01 — — US disclosed
US-20110009413-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2011-01-13 — — US disclosed
EP-2229371-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS University of Greenwich (GB) 2010-09-22 — — EP disclosed
WO-2009090431-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS UNIVERSITY OF GREENWICH (GB) 2009-07-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140155403-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS SCN1A, SCN1B, SCN3A MAPT 3296/4885MEN1 1245/4885KMT2A 2565/4885
US-20110009413-A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS CACNA1E, SCN2B, SCN3A MAPT 239/4885MEN1 664/4885KMT2A 3049/4885
US-20230167075-A1 INTERLEUKIN INHIBITORS IL2, IL1A, IL1B MAPT 206/4885MEN1 1801/4885KMT2A 2522/4885
US-20230165869-A1 DIAZINE AND TRIAZINE COMPOUNDS TO TREAT CYTOKINE STORM SYNDROME IFNG, TNF, IL1A MAPT 3577/4885MEN1 375/4885KMT2A 3565/4885
US-10576086-B2 Triazine derivatives as interferon-gamma inhibitors IFNG, IFNAR1, IRF3 MAPT 18/4885MEN1 2169/4885KMT2A 4677/4885
US-20180169105-A1 TRIAZINE DERIVATIVES AS INTERFERON-GAMMA INHIBITORS IFNG, IFNAR1, IRF3 MAPT 18/4885MEN1 2169/4885KMT2A 4677/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.