Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 3/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 3/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28384249 | 0.84 | ATM (0.46) | ACACBANPEPESR1ESR2PPARG | |
| SCHEMBL433224 | 0.84 | ESR1 (0.58) | ANPEPESR1ESR2ALDH1A1 | |
| SCHEMBL12321430 | 0.83 | CTSC (0.49) | ACACBANPEPESR1ESR2PPARG | |
| SCHEMBL31474258 | 0.83 | NOS2 (0.48) | ANPEPESR1ESR2PPARGMAPK1 | |
| SCHEMBL11925791 | 0.83 | NLRP3 (0.47) | ANPEPESR1ESR2MAPK1ALDH1A1 | |
| SCHEMBL10523997 | 0.83 | ANPEP (0.57) | ANPEPTHRBALDH1A1POLB | |
| SCHEMBL6817504 | 0.82 | PPARG (0.44) | ACACBPPARGPPARAALDH1A1KDM4E | |
| SCHEMBL10536462 | 0.81 | ALDH1A1 (0.47) | ACACBANPEPESR1ESR2MAPK1 | |
| SCHEMBL21763387 | 0.81 | ANPEP (0.52) | ACACBANPEPPPARGPPARA | |
| SCHEMBL8416993 | 0.78 | CYP3A4 (0.44) | ANPEPESR1ESR2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259085-B1 | 2-GUANIDINO-4-ARYLTHIAZOLES FOR TREATMENT OF PEPTIC ULCERS | PFIZER INC. (US) | 1991-08-21 | — | — | EP | disclosed |
| US-5026715-A | 2-guanidino-4-arylthiazoles for treatment of peptic ulcers | PFIZER INC. (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0161841-B1 | 2-(N-SUBSTITUTEGUANIDINO)-4-HETERO-ARYLTHIAZOLE ANTIULCER AGENTS | PFIZER INC. (US) | 1989-07-19 | — | — | EP | disclosed |
| EP-0259085-A1 | 2-Guanidino-4-arylthiazoles for treatment of peptic ulcers | PFIZER INC. (US) | 1988-03-09 | — | — | EP | disclosed |
| US-4560690-A | ANTISECRETORY AGENTS, HISTAMINE H2-ANTAGONISTS | PFIZER INC. (US) | 1985-12-24 | — | — | US | disclosed |
| EP-0161841-A1 | 2-(N-substituteguanidino)-4-hetero-arylthiazole antiulcer agents | PFIZER INC. (US) | 1985-11-21 | — | — | EP | disclosed |