SCHEMBL21763387

SCHEMBL21763387

COC(=O)C(C#N)Cc1ccc(-c2ccccc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ANPEP P15144 4/20 0.52
CTSK P43235 3/20 0.51
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
CTSH P09668 1/20 0.51
CYP2D6 P10635 1/20 0.51
CTSC P53634 1/20 0.51
HDAC1 Q13547 4/20 0.50
HDAC6 Q9UBN7 4/20 0.50
CTSS P25774 2/20 0.48
SRR Q9GZT4 2/20 0.47
PSAT1 Q9Y617 2/20 0.47
CTSB P07858 1/20 0.46
MME P08473 2/20 0.46
ACE P12821 2/20 0.46
CPA1 P15085 2/20 0.46
ACE2 Q9BYF1 2/20 0.46
ACACB O00763 1/20 0.46
PPARG P37231 3/20 0.46
PPARA Q07869 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10523997 0.91 ANPEP (0.57) ANPEPCTSKCTSCCTSSCTSB
SCHEMBL433224 0.83 ESR1 (0.58) ANPEPCTSKCYP1A2CYP3A4CTSS
SCHEMBL28384249 0.83 ATM (0.46) ANPEPCTSKACACBPPARGPPARA
SCHEMBL11925791 0.82 NLRP3 (0.47) ANPEPCYP3A4CTSC
SCHEMBL12321430 0.82 CTSC (0.49) ANPEPCTSCACACBPPARGPPARA
SCHEMBL31474258 0.82 NOS2 (0.48) ANPEPCTSKCTSSPPARG
SCHEMBL9788997 0.81 TAS1R3 (0.46) ANPEPACACBPPARGPPARA
SCHEMBL10536462 0.79 ALDH1A1 (0.47) ANPEPHDAC1HDAC6CTSBACACB
SCHEMBL6576829 0.78 ALDH1A1 (0.55) HDAC1HDAC6SRRPSAT1MME
SCHEMBL8416993 0.77 CYP3A4 (0.44) ANPEPCYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3359522-B1 PROCESS FOR PREPARATION OF N-BOC BIPHENYL ALANINOL CHIRAL QUEST SUZHOU CO LTD (CN) 2020-02-26 EP disclosed