Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | MGLL | Q99685 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | HPGD | P15428 | 5/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.68 |
| ▸ | PHGDH | O43175 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | FAAH | O00519 | 2/20 | 0.64 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (4-Bromophenyl)(Morpholino)Methanethione SCHEMBL8424996 | 0.82 | MGLL (1.00) | KMT2AMGLLALDH1A1HPGDHSD17B10 | |
| SCHEMBL19357081 | 0.81 | LMNA (1.00) | KMT2AMEN1MGLLALDH1A1HPGD | |
| (4-Chlorophenyl)(Morpholino)Methanethione SCHEMBL9268856 | 0.81 | ALDH1A1 (1.00) | KMT2AMEN1MGLLALDH1A1HPGD | |
| SCHEMBL13186487 | 0.80 | ALDH1A1 (0.78) | KMT2AMEN1MGLLALDH1A1HPGD | |
| Morpholino(Phenyl)Methanethione SCHEMBL9180076 | 0.80 | MGLL (0.79) | KMT2AMGLLALDH1A1HPGDHSD17B10 | |
| SCHEMBL13758203 | 0.79 | LMNA (0.57) | KMT2AMEN1MGLLALDH1A1HPGD | |
| SCHEMBL12871 | 0.79 | PHGDH (0.69) | KMT2AALDH1A1HPGDPHGDHTSHR | |
| SCHEMBL8108872 | 0.79 | MGLL (0.68) | KMT2AMEN1MGLLALDH1A1HPGD | |
| SCHEMBL8115934 | 0.78 | ALDH1A1 (1.00) | KMT2AMEN1MGLLALDH1A1HPGD | |
| SCHEMBL4893392 | 0.77 | LMNA (0.62) | KMT2AMEN1MGLLALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988822-A | Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4873340-A | Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1989-10-10 | — | — | US | disclosed |