Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MGLL | Q99685 | 2/20 | 0.60 |
| ▸ | FAAH | O00519 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3543531 | 0.85 | SMN1; SMN2 (0.63) | ALDH1A1MGLLFAAHKMT2AMEN1 | |
| SCHEMBL9792249 | 0.77 | KMT2A (0.70) | LMNAALDH1A1MGLLFAAHKMT2A | |
| SCHEMBL4893400 | 0.77 | SMN1; SMN2 (0.52) | ALDH1A1MGLLFAAHKMT2ARAB9A | |
| SCHEMBL19357081 | 0.77 | LMNA (1.00) | LMNAALDH1A1MGLLFAAHKMT2A | |
| SCHEMBL12871 | 0.76 | PHGDH (0.69) | LMNAALDH1A1KMT2ARAB9AHPGD | |
| SCHEMBL4397261 | 0.75 | ALDH1A1 (1.00) | LMNAALDH1A1MGLLFAAHKMT2A | |
| SCHEMBL12947818 | 0.75 | KMT2A (0.69) | LMNAALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL28612094 | 0.73 | LMNA (0.71) | LMNAALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL12123790 | 0.73 | ALDH1A1 (0.73) | LMNAALDH1A1KMT2AMEN1HTT | |
| SCHEMBL12301999 | 0.72 | CYP3A4 (0.60) | LMNAALDH1A1KMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293721-A1 | ARYLTHIOACETAMIDE CARBOXYLATE DERIVATIVES AS FKBP INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISEASES | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293721-A1 | ARYLTHIOACETAMIDE CARBOXYLATE DERIVATIVES AS FKBP INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISEASES | FKBP3, FKBP2, FKBP1B | LMNA 4536/4885ALDH1A1 1904/4885MGLL 4824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.