Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.30 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9497939 | 0.88 | RECQL (0.38) | ESR2DPP4RECQL | |
| Fumaric Acid SCHEMBL9795500 | 0.88 | PDE5A (0.33) | PDE5AESR2 | |
| Fumaric Acid SCHEMBL9795581 | 0.82 | TSHR (0.36) | PDE5A | |
| Fumaric Acid SCHEMBL9795207 | 0.79 | SLC6A5 (0.37) | PDE5AESR2 | |
| Fumaric Acid SCHEMBL9795267 | 0.76 | TSHR (0.40) | PDE5A | |
| Fumaric Acid SCHEMBL9795414 | 0.76 | BCHE (0.36) | — | |
| Fumaric Acid SCHEMBL9795259 | 0.76 | PDE5A (0.37) | PDE5A | |
| Fumaric Acid SCHEMBL9795542 | 0.75 | ALDH1A1 (0.46) | PDE5A | |
| SCHEMBL9501592 | 0.75 | RECQL (0.36) | ESR2DPP4RECQL | |
| Fumaric Acid SCHEMBL9795218 | 0.75 | CA1 (0.36) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037849-A | For treatment of heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1991-08-06 | — | — | US | disclosed |