Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.59 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.59 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9752732 | 0.95 | GABRA1 (0.64) | GABRA1GABRA5GABRB2SMN1; SMN2KDM4E | |
| Necopidem SCHEMBL1061121 | 0.81 | GABRA1 (0.57) | GABRA1GABRA5GABRB2KDM4ENPC1 | |
| SCHEMBL9797224 | 0.79 | PLAU (0.47) | GABRA1GABRA5GABRB2SMN1; SMN2KDM4E | |
| Saripidem SCHEMBL1061054 | 0.74 | GABRB2 (1.00) | GABRA1GABRA5GABRB2SMN1; SMN2KDM4E | |
| SCHEMBL10385117 | 0.72 | GABRA1 (0.66) | GABRA1GABRA5GABRB2KDM4ENPC1 | |
| SCHEMBL9788651 | 0.70 | GABRA1 (0.52) | GABRA1GABRA5GABRB2KDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL10385129 | 0.70 | GABRB2 (0.51) | GABRA1GABRA5GABRB2KDM4E | |
| SCHEMBL10467219 | 0.69 | GABRA1 (0.55) | GABRA1GABRA5GABRB2KDM4EALDH1A1 | |
| SCHEMBL9788667 | 0.69 | GABRA1 (0.55) | GABRA1GABRA5GABRB2KDM4EALDH1A1 | |
| SCHEMBL9788699 | 0.69 | GABRA1 (0.58) | GABRA1GABRA5GABRB2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5064836-A | Imidazopyridine for use as an anaesthetic | SYNTHELABO (FR) | 1991-11-12 | — | — | US | disclosed |