Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 1.00 |
| ▸ | MAOB | P27338 | 6/20 | 0.73 |
| ▸ | GPR35 | Q9HC97 | 6/20 | 0.69 |
| ▸ | CA12 | O43570 | 5/20 | 0.69 |
| ▸ | CA1 | P00915 | 5/20 | 0.69 |
| ▸ | CA9 | Q16790 | 5/20 | 0.69 |
| ▸ | CA6 | P23280 | 4/20 | 0.69 |
| ▸ | CA7 | P43166 | 4/20 | 0.69 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.69 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.69 |
| ▸ | CA2 | P00918 | 4/20 | 0.69 |
| ▸ | CA4 | P22748 | 3/20 | 0.69 |
| ▸ | CA5A | P35218 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.69 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.69 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.69 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29785071 | 1.00 | MAOA (1.00) | MAOAMAOBGPR35CA12CA1 | |
| SCHEMBL1367700 | 0.88 | MAOA (0.78) | MAOAMAOBCA12CA1CA9 | |
| SCHEMBL37883 | 0.86 | MAOA (0.76) | MAOAMAOBGPR35CA12CA1 | |
| SCHEMBL11510368 | 0.85 | MAOA (0.73) | MAOAMAOBGPR35CA12CA1 | |
| SCHEMBL11319226 | 0.83 | MAOA (1.00) | MAOAMAOBKDM4EALDH1A1HPGD | |
| SCHEMBL11266285 | 0.83 | MAOA (0.71) | MAOAMAOBGPR35CA12CA1 | |
| SCHEMBL9068774 | 0.81 | MAOA (0.69) | MAOAMAOBGPR35CA12CA1 | |
| SCHEMBL980099 | 0.81 | MAOA (0.69) | MAOAMAOBGPR35CA12CA1 | |
| SCHEMBL31315658 | 0.81 | MAOA (0.69) | MAOAMAOBGPR35CA12CA1 | |
| SCHEMBL569881 | 0.81 | GPR35 (1.00) | MAOAMAOBGPR35CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112939916-B | Method for synthesizing coumarin-3-carboxylic acid compounds by one-pot two-step method | 河南中烟工业有限责任公司 | 2022-08-19 | — | — | CN | disclosed |
| CN-113024499-A | Green synthesis method of coumarin-3-carboxylic acid compounds | 河南中烟工业有限责任公司 | 2021-06-25 | — | — | CN | disclosed |
| CN-112939916-A | Method for synthesizing coumarin-3-carboxylic acid compounds by one-pot two-step method | 河南中烟工业有限责任公司 | 2021-06-11 | — | — | CN | disclosed |
| US-8642788-B2 | Activators of executioner procaspases 3, 6 and 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-02-04 | — | — | US | disclosed |
| CN-101965189-A | Activators of pro-caspase 3, 6 and 7 | UNIV CALIFORNIA | 2011-02-02 | — | — | CN | disclosed |
| US-20110021522-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-27 | — | — | US | disclosed |
| EP-2237784-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | The Regents of the University of California (US) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009089508-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-07-16 | — | — | WO | disclosed |
| US-4343938-A | 7-[Dα-(Coumarin-3-carboxamido)arylacetamido]-cephalosporanic acids or salts | AMERICAN CYANAMID COMPANY (US) | 1982-08-10 | — | — | US | disclosed |
| US-4317774-A | 6-[D-α-(Coumarin-3-carboxamido)arylacetamido]-penicillanic acids or salts | AMERICAN CYANAMID COMPANY (US) | 1982-03-02 | — | — | US | disclosed |
| US-4303664-A | Novel penicillin derivatives containing a coumarin nucleus and medicines containing the same | TEIJIN LIMITED (JP) | 1981-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021522-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | CASP7, CASP3, CASP6 | MAOA 2101/4885MAOB 3235/4885GPR35 4234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.