SCHEMBL9800228

SCHEMBL9800228

CCOC1CCCC(=O)N1C

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
BRD4 O60885 1/20 0.33
BRD2 P25440 1/20 0.33
CHRNB2 P17787 1/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
CHRNA7 P36544 1/20 0.32
CHRNA4 P43681 1/20 0.32
P2RX7 Q99572 2/20 0.32
TDP1 Q9NUW8 1/20 0.31
HCRTR1 O43613 2/20 0.30
HCRTR2 O43614 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11492801 0.77 TSHR (0.35) HCRTR1HCRTR2
SCHEMBL7657267 0.76
SCHEMBL17817923 0.73 P2RX7 (0.33) BRD4BRD2CHRNB2CHRNB4CHRNA3
SCHEMBL16421826 0.71 BRD4 (0.37) ALDH1A1BRD4BRD2CHRNB2CHRNB4
SCHEMBL16546878 0.69 FKBP1A (0.42) ALDH1A1SMN1; SMN2P2RX7
SCHEMBL9800244 0.69 ALDH1A1 (0.34) ALDH1A1SMN1; SMN2
SCHEMBL9800254 0.69 ALDH1A1 (0.34) ALDH1A1SMN1; SMN2
SCHEMBL9800221 0.68 HTR1A (0.32) ALDH1A1SMN1; SMN2
SCHEMBL9800302 0.68
SCHEMBL1303658 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0417143-A1 CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL THE UPJOHN COMPANY (US) 1991-03-20 EP claimed
WO-1989011856-A2 CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL THE UPJOHN COMPANY (US) 1989-12-14 WO claimed
EP-0417143-A1 CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL THE UPJOHN COMPANY (US) 1991-03-20 EP disclosed
WO-1989011856-A2 CYCLIC LACTAMS FOR CHOLESTEROL AND ATHEROSCLEROSIS CONTROL THE UPJOHN COMPANY (US) 1989-12-14 WO disclosed