Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9803059 | 0.73 | ALDH1A1 (0.49) | KDM4EGAAALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL8085348 | 0.69 | CRBN (0.38) | KDM4EGAAALDH1A1LMNACRBN | |
| SCHEMBL7807801 | 0.66 | CRBN (0.40) | KDM4EGAAALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL9802754 | 0.66 | CRBN (0.46) | KDM4EGAAALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL10495608 | 0.64 | ALDH1A1 (0.52) | KDM4EGAAALDH1A1HSD17B10L3MBTL1 | |
| SCHEMBL162371 | 0.64 | — | — | |
| SCHEMBL10053017 | 0.64 | — | — | |
| SCHEMBL14387952 | 0.64 | — | — | |
| SCHEMBL5696232 | 0.63 | CRBN (0.32) | GAACRBN | |
| SCHEMBL9803448 | 0.62 | MAPT (0.33) | KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0338228-A2 | Use of quinoline-2,5-diones in a medicament having an analgesic, antipyretic and/or antiphlogistic activity | Dr. Karl Thomae GmbH (DE) | 1989-10-25 | — | — | EP | claimed |
| US-5068334-A | Analgesics and antipyretics | KARL THOMAE GMBH (DE) | 1991-11-26 | — | — | US | disclosed |
| EP-0338228-A2 | Use of quinoline-2,5-diones in a medicament having an analgesic, antipyretic and/or antiphlogistic activity | Dr. Karl Thomae GmbH (DE) | 1989-10-25 | — | — | EP | disclosed |