Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 3/20 | 0.59 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.59 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.59 |
| ▸ | PDE2A | O00408 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9803382 | 0.90 | PDE2A (0.49) | PDE1APDE1BPDE1CPDE2AMEN1 | |
| SCHEMBL8571168 | 0.81 | ADORA2A (0.41) | PDE1APDE1BPDE1CPDE2AMEN1 | |
| SCHEMBL5688395 | 0.78 | PDE2A (0.60) | PDE1APDE1BPDE1CPDE2AMEN1 | |
| SCHEMBL25249437 | 0.76 | PDE1A (0.69) | PDE1APDE1BPDE1CPDE2AMEN1 | |
| SCHEMBL897036 | 0.74 | PDE1A (1.00) | PDE1APDE1BPDE1CPDE2AMEN1 | |
| SCHEMBL2472008 | 0.74 | PDE1A (0.61) | PDE1APDE1BPDE1CPDE2AMEN1 | |
| SCHEMBL2948025 | 0.74 | PDE1A (0.61) | PDE1APDE1BPDE1CPDE2AMEN1 | |
| SCHEMBL7918903 | 0.74 | ADORA1 (0.57) | PDE1APDE1BPDE1CPDE2APDE4A | |
| SCHEMBL11066305 | 0.73 | SIRT1 (0.54) | PDE1APDE1BPDE1CPDE2ACYP1A2 | |
| SCHEMBL461786 | 0.72 | PDE2A (0.62) | PDE1APDE1BPDE1CPDE2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0069958-B2 | Method for the preparation of gastro compatible pharmaceutical forms of xanthine derivatives. | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-27 | — | — | EP | disclosed |
| EP-0069958-B1 | Method for the preparation of gastro compatible pharmaceutical forms of xanthine derivatives. | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-04-02 | — | — | EP | disclosed |
| US-4542011-A | PROTECTIVE COATINGS | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-09-17 | — | — | US | disclosed |
| EP-0069958-A2 | Method for the preparation of gastro compatible pharmaceutical forms of xanthine derivatives. | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-01-19 | — | — | EP | disclosed |