Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9859685 | 0.98 | MAPT (0.40) | MAPTALDH1A1TSHRALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL9859688 | 0.96 | MAPT (0.41) | MAPTALDH1A1TSHRALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL10936946 | 0.96 | MAPT (0.41) | MAPTALDH1A1TSHRALOX15HSD17B10 | |
| SCHEMBL10934891 | 0.96 | MAPT (0.43) | MAPTALDH1A1TSHRALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL9859101 | 0.79 | S100B (0.50) | MAPTALDH1A1TSHRALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL11875836 | 0.78 | S100B (0.53) | MAPTALDH1A1TSHRALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL9803975 | 0.77 | S100B (0.51) | MAPTALDH1A1TSHRALOX15HSD17B10 | |
| SCHEMBL11061844 | 0.76 | S100B (0.55) | MAPTALDH1A1TSHRALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL8948391 | 0.75 | ALDH1A1 (0.39) | ALDH1A1TSHRTDP1CYP3A4TP53 | |
| Hydrochloric Acid SCHEMBL9859387 | 0.75 | NQO2 (0.38) | MAPTALDH1A1TSHRHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985344-A | Radiation imaging process for forming pattern without alkali-soluble polymer underlayer and water soluble radiation-sensitive diazonium salt overlayer | HITACHI, LTD. (JP) | 1991-01-15 | — | — | US | disclosed |