SCHEMBL9811275

SCHEMBL9811275

O=C(Nc1n[c]nc(F)n1)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 2/20 0.53
KMT2A Q03164 2/20 0.47
MEN1 O00255 1/20 0.47
NPC1 O15118 6/20 0.46
RAB9A P51151 6/20 0.46
ADORA3 P0DMS8 3/20 0.46
ADORA2A P29274 2/20 0.46
F2 P00734 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
F12 P00748 1/20 0.46
MAPK1 P28482 1/20 0.44
SMN1; SMN2 Q16637 5/20 0.44
MAPT P10636 2/20 0.44
GAA P10253 1/20 0.44
HTT P42858 1/20 0.44
LMNA P02545 1/20 0.43
PKM P14618 1/20 0.43
MAOB P27338 1/20 0.43
HPGD P15428 2/20 0.43
CYP1A2 P05177 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3299661 0.75 ADORA1 (0.70) ADORA1KMT2AMEN1NPC1RAB9A
SCHEMBL27979612 0.70 F2 (0.66) ADORA1KMT2AMEN1NPC1RAB9A
SCHEMBL4542768 0.69 BCAT2 (0.58) ADORA1KMT2AMEN1NPC1RAB9A
SCHEMBL6498848 0.69 ADORA1 (1.00) ADORA1ADORA3ADORA2AF2F12
SCHEMBL997872 0.69 RAB9A (0.59) ADORA1KMT2AMEN1NPC1RAB9A
SCHEMBL2623093 0.68 L3MBTL1 (0.64) ADORA1KMT2AMEN1NPC1RAB9A
SCHEMBL9564262 0.68 ADORA1 (0.60) ADORA1KMT2AMEN1NPC1RAB9A
SCHEMBL9504179 0.68 ADORA1 (0.65) ADORA1KMT2AMEN1NPC1RAB9A
SCHEMBL9566583 0.68 ADORA1 (0.70) ADORA1KMT2AMEN1ADORA3ADORA2A
SCHEMBL2623094 0.68 ADORA1 (0.60) ADORA1KMT2AMEN1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0286021-B1 REACTIVE AZO DYES BASF Aktiengesellschaft (DE) 1991-06-26 EP disclosed
US-4897469-A Aniline series azo reactive dyes ortho- or para-substituted by vinyl sulfonyl reactive groups BASF AKTIENGESELLSCHAFT (DE) 1990-01-30 US disclosed
US-4806640-A Triphendioxazine reactive dyestuffs BAYER AKTIENGESELLSCHAFT (DE) 1989-02-21 US disclosed
EP-0286021-A2 Reactive azo dyes BASF Aktiengesellschaft (DE) 1988-10-12 EP disclosed
US-4591643-A Triphendioxazine reactive dyestuffs BAYER AKTIENGESELLSCHAFT (DE) 1986-05-27 US disclosed