Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 15/20 | 0.50 |
| ▸ | DRD2 | P14416 | 9/20 | 0.50 |
| ▸ | DRD3 | P35462 | 6/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9298267 | 0.81 | SLC18A3 (0.57) | DRD2 | |
| SCHEMBL9811461 | 0.79 | HRH3 (0.46) | DRD2FDPS | |
| SCHEMBL9811477 | 0.77 | FDPS (0.49) | FDPSALDH1A1 | |
| SCHEMBL7212038 | 0.77 | DRD4 (0.59) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL9811498 | 0.77 | ALDH1A1 (0.53) | DRD4DRD2DRD3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7660483 | 0.76 | DRD4 (0.58) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL9811540 | 0.75 | ALDH1A1 (0.40) | DRD4DRD2DRD3FDPSALDH1A1 | |
| SCHEMBL6198971 | 0.75 | ADRA1D (0.55) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL7833509 | 0.74 | DRD2 (0.59) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL8003967 | 0.74 | DRD4 (0.52) | DRD4DRD2DRD3ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272208-B1 | AROMATICALLY SUBSTITUTED AZACYCLO-ALKYLALKANEDIPHOSPHONIC ACIDS | CIBA-GEIGY AG (CH) | 1991-06-12 | — | — | EP | disclosed |
| US-4871720-A | Aromatically substituted azacycloalkyl-alkanediphosphonic acids useful for the treatment of illnesses that can be attributed to calcium metabolism disorders | CIBA-GEIGY CORPORATION (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0272208-A1 | Aromatically substituted azacyclo-alkylalkanediphosphonic acids | CIBA-GEIGY AG (CH) | 1988-06-22 | — | — | EP | disclosed |