Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL341222 | 0.73 | MAOA (0.43) | DRD3ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL23051919 | 0.67 | OPRK1 (0.35) | DRD2DRD3ALDH1A1LMNAMAPK1 | |
| SCHEMBL9813251 | 0.66 | ALDH1A1 (0.43) | DRD2DRD3ALDH1A1LMNAMAPK1 | |
| SCHEMBL9813140 | 0.66 | MAOA (0.51) | DRD3ALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8715342 | 0.65 | TTR (0.32) | DRD3MEN1KMT2AL3MBTL1 | |
| SCHEMBL9813219 | 0.64 | MAPT (0.42) | DRD2DRD3LMNAMAPT | |
| SCHEMBL13023260 | 0.63 | ACHE (0.41) | ALDH1A1LMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL14281164 | 0.63 | HTR7 (0.35) | ALDH1A1LMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL8711081 | 0.62 | ALDH1A1 (0.33) | DRD3ALDH1A1MAPK1MAPTMEN1 | |
| SCHEMBL13023396 | 0.61 | ACHE (0.35) | DRD2DRD3ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0138481-B1 | LEUKOTRIENE BIOSYNTHESIS INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1991-06-26 | — | — | EP | disclosed |
| US-4845083-A | PHENOTHIAZINE DERIVATIVES AND ANALOGS | MERCK FROSST CANADA, INC. (CA) | 1989-07-04 | — | — | US | disclosed |
| EP-0138481-A2 | Leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1985-04-24 | — | — | EP | disclosed |